DESCRIPTION: Vestibular compensation animation produced for Johnson & Johnson.
The Vestibular system comprises of vestibular apparatus & vestibular nuclei. Situated in the Brain stem, vestibular nuclei plays a central & critical role.
Commissural fibers crossing the midline connect the paired nuclei, ensuring bilateral coordinated functioning of the vestibular system.
The commissural fibers transmit inhibitory impulses between the vestibular nuclei which are essential for maintaining balance in the firing activity. This phenomenon is called Inhibitory commissural mechanism.
In the event of unilateral labrynthine damage, at rest, the ipsilesional vestibular nucleus receives no inputs, while the contralesional nucleus continue receive inputs from the normal labyrinth and becomes hyperactive due to weak inhibitory inputs from ipsilesional vestibular nucleus, this creates an imbalance in the firing rates of the two vestibular nuclei.
This imbalance is further aggravated as ipsilesional vestibular nucleus becomes hypoactive due to continuous inhibitory inputs through commissural inhibition from contralesional vestibular nucleus.
This imbalance results in patients experiencing dizziness/vertigo.
The Natural process of vestibular compensation involves reduction in hyperactivity of contralesional vestibular nuclei and restoration of firing activity in hypoactive ipsilesional vestibular nuclei.
There are four mechanisms, which operate in parallel and synergistically to bring about vestibular compensation.
Mechanisms involved in restoration of firing activity in ipsilesional hypoactive vestibular nucleus.
1. Glycine and GABA are the inhibitory neurotransmitters of the commissural system. At ipsilesional vestibular nucleus down regulation of GABA & glycine receptors results in decreased responsiveness to the inhibitory inputs from contralesional vestibular nucleus.
2. There is upregulation of intrinsic electrophysiological excitability of Ipsilesional vestibular nucleus neurons
3. There is gradual & activity-dependent reorganization of synaptic connectivity. As a result Ipsilesional Vestibular nuclei neuron starts receiving inputs from contralesional side.
Mechanisms involved in reducing the hyperactivity of contralesional vestibular nucleus.
4. Cerebellum exhibits Cerebello-cortical plasticity inhibiting the activity of contralesional Vestibular nuclei neurons resulting in reduction in inhibitory inputs to the Ipsilesional Vestibular nucleus cells.
Let’s explore the role of calcium channel blocker like cinnarizine in vestibular compensation process.
Effect of CCB on intact, Hyperactive Contralesional vestibular nuclei
CCB contributes in reducing the hyperactivity of contralesional vestibular nucleus by 2 mechanisms.
The Central role is attributed to the fact that CCB increases the excitability of GABAnergic Purkinje cells in the cerebellum. This contributes to the cerebellar effect of direct inhibition of Hyperactive Vestibular nuclei on the side of the intact labyrinth.
At labyrinthine level, CCB like Cinnarizine prevents entry of Calcium ions into the vestibular hair cells reducing release of neurotransmitters, resulting in decreased firing frequency. This contributes to reducing the hyperactivity of Contralesional Vestibular nuclei.
Effect of CCB on deafferented, ipsilesional vestibular nuclei
CCB contributes in restoration of firing activity in ipsilesional hypoactive vestibular nucleus.
Deafferentation may cause excessive calcium influx or calcium overload in vestibular neurons. This overload eventually leads to neuronal cell death due to its effect on metabolic processes. This cell death further depresses the resting activity of the ipsilesional vestibular nucleus neurons.
Calcium channel blockers by inhibiting intracellular calcium influx may contribute to the compensation process by preventing the calcium overload and support the recovery of the vestibular nucleus neurons.
Additionally Cinnarizine enhances the responsiveness of vestibular neucleus neurons to vestibular nerve stimulation by improving cerebral and inner ear microcirculation.
Vestibular rehabilitation exercises promote rewiring of synaptic connectivity. Cinnarizine produce selective effect on vestibular system without affecting reticular activating system and thalamo – cortical pathway. Thus it does not impact alertness and vigilance of the patients and may not interfere with vestibular rehabilitation exercises.
Thus cinnarizine may support natural process of vestibular compensation.
#featured
For more info please visit http://www.santanu.biz
Page 1
For more videos, please hop over to Santanu Production Mumbai YouTube page and subscribe.
Our newer video making techniques will surely help you with fresh ideas to grow your brand visibility.
Corporate profile videos, brand videos that includes branding, corporate values, industry shoot, office premise, products, employees, legacy, certifications, QC, HSQE, CSR, rewards and recognition among others. Creation of the classic Corporate Videos are our forte, nevertheless, we have mastered making all forms of corporate communication videos.
Commercial Spots, Television Commercials, TV Spots or advertisements as we call them, are a high value production we have been engaged in for years. Here, novelty is the name of the game. We specialise in smart concepts that makes your 30 second spot stand out among the clutter
Social Media Spots or advertisements as we call them, are a high value production we have been engaged in for years. Here, novelty is the name of the game. We specialise in smart concepts that makes your 30 second spot stand out among the clutter
Our product video services include researching and bringing out every USP of your products so that they stand out firmly against your competition. The product shoot style are always eye-candy and display a larger-than-life image of your brand that create a lasting image in the minds of your prospects and customers
Employee motivation is a full-time excercise the marketing and human resource departments are always engaged in. We have been creating numerous motivational audiovisual for several pharmaceutical, banking and other industries that are creative, engaging, full of thrill, and impart a lot of energy to their employees. Our clients keep coming back to us for new motivational AVs because they do make an impact
Training a large number of employees, channel partners or end users across different locations on new SOPS, or a new product may consume a lot of time & resource for an organization. Our training videos have been helping many clients such as ICICI Prudential, HDFC Bank, Pfizer create quality training material in a lucid and articulate manner. These are supported by ample use of graphics and other creatives
Roleplay videos are the quickest way of deploying training videos. They are helpful in demonstrating soft skills, service training, how to sell a product, or training customer support teams. Roleplay videos involve capturing ideal scenarios of interaction between a few individuals playing the role of seller or buyer. Our multi-camera setups capture every individual and their gestures in detail from different angles so that the end-user of the video can quickly learn the mannerisms and style of communicating from an ideal scenario. We often employee professional actors for such jobs who carry the film highly professionally using a thoughtful and a foresighted script
To explain a business process, a workflow, or a schematic to your target group using simpler graphics and animation you need explainer videos. Graphics with animations create wonders for an easier understanding of concepts. No wonder explainer videos have gained popularity in recent times. Our explainer videos better engage the audience with captivating scripts, lively visuals, foot-tapping music along with professional voiceovers
We specialize creating quality 2D and 3D animation videos for the last 3 decades to demonstrate various products, infrastructures, systems, processes and machines. Animations help in visualizing and understanding of concepts easily
When was the last time you read the instruction manual to use your smartphone? Today's generation needs instant help. We make short video based product How-To or instructional videos that are self-explanatory. You can save your money on print,and a dedicated support team to service every mundane customer query. Simply put the video on your website or YouTube and serve the link
We make safety and CSR videos often mandatory for Industries. Our safety videos bring awareness among employees, contractors and vistors at the plant sites for possible hazards in the most understandable and visual format. Beyond mere documentation, our well-crafted Corporate Social Responsibility or CSR videos have an emotional touch that bring social goodwill and genuine trust towards your brand.
We make safety and CSR videos often mandatory for Industries. Our safety videos bring awareness among employees, contractors and vistors at the plant sites for possible hazards in the most understandable and visual format. Beyond mere documentation, our well-crafted Corporate Social Responsibility or CSR videos have an emotional touch that bring social goodwill and genuine trust towards your brand.
The biggest daunting task for architects is not in designing a building or an interior, but presenting it most impressively. Our Realistic, lifelike 3D animation opens up possibilities for better visualization and selling your ideas to impress investors
A video testimonial is an audiovisual of a customer, a client, employee, or other stakeholder praising a company, talking about how your company’s product or service has helped them or what they like about the company. Our creative testimonial videos appear candid and genuine as we pamper our speakers, rehearse them well, make them comfortable, and sometimes use teleprompters
To capture the attention of a passerby in his brief view time, corporate videos for trade fairs are designed with rapid movement of shots, eye candy VFX, foot tapping music, no voice, ample animated large text supers with special effects ande glimpses of important highlights. Events are candid collection of real people footage capture by super smart cmaera team for the best angles & moments. Over the decades we have mastered both.
Subsequent to creating an audiovisual in English, often our biggest byproduct is dubbing those audiovisuals in foreign or vurnacular languages to reach a wider audience. For years we are associated with many world-languages audiovisual transcripts writers, translators, language quality supervisors, voice dubbing artists, and studios across the globe. What's more, your brand gets a global footprint.
AI or Artificial Intelligence based video content offer relatively economic soloutions, compared to using real actors, voiceovers artists and stunning visuals. They also give consistent output and faster turnarounds.